LEAD, BIOINFORMATICS AND SPECIAL PROJECTS Job at University of Washington
University of Washington Seattle, WA 98195
$6,467 - $12,000 a month
Benefits:
As a UW employee, you will enjoy generous benefits and work/life programs. For a complete description of our benefits for this position, please visit our website, click here.
As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem-solving skills and dedication to build stronger minds and a healthier world.
UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty.
Background on the University of Washington and the BBI:
The University of Washington (UW) is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service. Our staff not only enjoys outstanding benefits and professional growth opportunities, but also an environment noted for diversity, community involvement, intellectual excitement, artistic pursuits, and natural beauty.
The Brotman Baty Institute (BBI) for Precision Medicine was co-founded by collaborative agreement between the University of Washington, the Fred Hutchinson Cancer Research Center and Seattle Children’s Hospital. BBI’s mission is to take advantage of Seattle’s unique ecosystem and collaborative culture towards having a transformative impact on biomedical research and patient outcomes with precision medicine. BBI works at the intersection of technology development and medicine in areas including medical genetics, cancer biology, infectious disease and technology development.
Position Summary:
We have an outstanding opportunity for a Lead, Bioinformatics and Special Projects (payroll title: Research Scientist/Engineer 4) to lead analyses related to a variety of BBI research areas, including single cell sequencing, cell-free DNA, and saturation genome editing. The position will play an important role in the development and maintenance of research-related analysis pipelines, the design and execution of clinical validation studies, and other Institute genomics projects.
The Lead, Bioinformatics and Special Projects will support and advance the Institute’s genomics initiatives in several ways. First, the Scientist will develop, improve, and standardize the computational platforms for analysis and visualization of data across various Institute projects. Second, the Scientist will use, and assist others in using, those platforms to perform data analysis on existing and future Institute datasets. Third, the Scientist will design and execute independent research directed toward an Institute scientific focus area.
A primary duty of the Lead, Bioinformatics and Special Projects is to develop and maintain data analysis pipelines for use by BBI staff and Investigators. The Scientist will leverage local high-performance computing environments and cloud-based resources towards this goal. The successful candidate will demonstrate expertise in creative problem-solving and critical thinking, as well as a strong familiarity with existing tools and methods in genomics data analysis.
The Lead, Bioinformatics and Special Projects will use these pipelines, and assist others in using these pipelines, to address research questions using Institute datasets. The Scientist will apply domain-specific knowledge in analyzing and summarizing conclusions from these analyses. The Scientist will collaborate with Institute Investigators to define and answer research questions for Investigator-led projects. The Scientist will also develop and communicate best practices for processing complex genomics data.
The Lead, Bioinformatics and Special Projects will also propose and lead research endeavors. These research endeavors may include cell-free DNA technology development and/or other independent research projects, and are likely to involve the use of existing BBI datasets and the generation of new datasets through experimentation. The successful candidate will possess the ability to dissect and analyze complex research problems using a multitude of programming languages and computational tools, as well as the ability to design and lead wet lab research. The Scientist will be responsible for directing the preparation of major proposals and presentations, and will play a lead role in the identification and/or acquisition of research funding.
DUTIES AND RESPONSIBILITIES
Data Science Service and Support (35%)
Develop, maintain, harmonize and streamline algorithms, pipelines and computational tools related to research projects across BBI.
Maintain best practices in data science and bioinformatics.
Participate in the design, development, and implementation of data science solutions.
Provide technical expertise, guidance, and research to support assigned projects, and help coordinate issues amongst customers and peers.
Drive clinical validation studies in partnership with the Department of Lab Medicine and Pathology (30%)
Design and execute clinical validation study of UW Medicine’s cfDNA test (MONC).
Lead other clinical validation efforts related to low-pass WGS assay, allograft monitoring etc.
Lead independent research (35%)
Define, launch and execute studies related to novel approaches to cfDNA interpretation, analysis, and to better explain variance.
Develop experimental methods to expand and extend our understanding of cfDNA methods to make the technology more effective.
Prepare reports and presentations for research projects, including collaborations as part of international consortia, group meetings and national conferences.
Prepare and submit grants to support future and ongoing research.
Thrive in a fast-paced work environment that requires independent self-direction with an aptitude for team collaboration and open communication.
MINIMUM REQUIREMENTS
BS in human genetics, bioinformatics, computer sciences or related field, or equivalent experience
A minimum 5 years of experience working with next-generation sequencing data and relevant tools for bioinformatics analysis, in either a professional or academic setting
Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.
ADDITIONAL REQUIREMENTS
Good understanding of human genetics
Strong knowledge of exploratory data analyses
Proficiency in common programming languages and computing environments for genomic data analysis, including Linux, Python and/or R, and AWS or other cloud providers
Experience working with high performance computing environments such as SGE/UGE and/or Slurm clusters
Ability to manage projects and solve problems independently
Experience in collaboration with interdisciplinary teams
Strong written and oral communication skills
DESIRED QUALIFICATIONS
Masters or Ph.D., or foreign equivalent, in human genetics, bioinformatics, computer sciences, or related field
Experience working with command line-based software for genomics data analysis (e.g. BWA, GATK, SAMtools)
Working understanding of common laboratory protocols
Demonstrated advanced skill level, knowledge, and proficiency in the application of data science tools and methods to applied next generation sequencing and pipeline-building problems; R or Python required
Demonstrated experience in accessing, querying, and manipulating multi-dimensional data sources, including multiple source systems from databases, flat files, free text, streaming, etc.
Experience with data visualization for non-technical audiences
Ability to work with cross-functional teams to coordinate assigned work and accomplish genomics objectives
Excellent communication, teamwork, and collaboration skills
Proficiency in Unix/Linux operating systems and command-line interfaces
Experience with high-performance computing environments and clusters, such as SGE/UGE and Slurm
Experience with cloud-based tools for data science, including at least one of Amazon Web Services,
Google Cloud Services, or Microsoft Azure
Comfortable with public speaking and presentations to audiences of 10 or more
Ability to solve and resolve complex technical problems; taking a new perspective using existing solutions
Ability to apply best practices and knowledge of data science to improve products, processes, or services
Ability to interpret customer needs, assess requirements, and identify solutions to nonstandard requests
Ability to develop and maintain effective working relationships including the resolution of difficult issues
Ability to manage and coordinate small projects or programs with manageable risks and resource requirements
Ability to interpret extensive variety of technical instruction and deal with complex variables involved in the field of genomics
Ability to provide bioinformatics outreach to clients/collaborators in the field of informatics and genomics
Strong critical thinking, analytical and problem-solving skills, and ability to think creatively
Strong understanding of data science concepts and techniques
Understanding of security and privacy issues
Able to work independently, with minimal supervision
No formal direct reports at this time, but possible in the future
Application Process:
The application process may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty.
Background on the University of Washington and the BBI:
The University of Washington (UW) is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service. Our staff not only enjoys outstanding benefits and professional growth opportunities, but also an environment noted for diversity, community involvement, intellectual excitement, artistic pursuits, and natural beauty.
The Brotman Baty Institute (BBI) for Precision Medicine was co-founded by collaborative agreement between the University of Washington, the Fred Hutchinson Cancer Research Center and Seattle Children’s Hospital. BBI’s mission is to take advantage of Seattle’s unique ecosystem and collaborative culture towards having a transformative impact on biomedical research and patient outcomes with precision medicine. BBI works at the intersection of technology development and medicine in areas including medical genetics, cancer biology, infectious disease and technology development.
Position Summary:
We have an outstanding opportunity for a Lead, Bioinformatics and Special Projects (payroll title: Research Scientist/Engineer 4) to lead analyses related to a variety of BBI research areas, including single cell sequencing, cell-free DNA, and saturation genome editing. The position will play an important role in the development and maintenance of research-related analysis pipelines, the design and execution of clinical validation studies, and other Institute genomics projects.
The Lead, Bioinformatics and Special Projects will support and advance the Institute’s genomics initiatives in several ways. First, the Scientist will develop, improve, and standardize the computational platforms for analysis and visualization of data across various Institute projects. Second, the Scientist will use, and assist others in using, those platforms to perform data analysis on existing and future Institute datasets. Third, the Scientist will design and execute independent research directed toward an Institute scientific focus area.
A primary duty of the Lead, Bioinformatics and Special Projects is to develop and maintain data analysis pipelines for use by BBI staff and Investigators. The Scientist will leverage local high-performance computing environments and cloud-based resources towards this goal. The successful candidate will demonstrate expertise in creative problem-solving and critical thinking, as well as a strong familiarity with existing tools and methods in genomics data analysis.
The Lead, Bioinformatics and Special Projects will use these pipelines, and assist others in using these pipelines, to address research questions using Institute datasets. The Scientist will apply domain-specific knowledge in analyzing and summarizing conclusions from these analyses. The Scientist will collaborate with Institute Investigators to define and answer research questions for Investigator-led projects. The Scientist will also develop and communicate best practices for processing complex genomics data.
The Lead, Bioinformatics and Special Projects will also propose and lead research endeavors. These research endeavors may include cell-free DNA technology development and/or other independent research projects, and are likely to involve the use of existing BBI datasets and the generation of new datasets through experimentation. The successful candidate will possess the ability to dissect and analyze complex research problems using a multitude of programming languages and computational tools, as well as the ability to design and lead wet lab research. The Scientist will be responsible for directing the preparation of major proposals and presentations, and will play a lead role in the identification and/or acquisition of research funding.
DUTIES AND RESPONSIBILITIES
Data Science Service and Support (35%)
Drive clinical validation studies in partnership with the Department of Lab Medicine and Pathology (30%)
Lead independent research (35%)
MINIMUM REQUIREMENTS
Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.
ADDITIONAL REQUIREMENTS
DESIRED QUALIFICATIONS
Application Process:
The application process may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.
The University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, national origin, age, protected veteran or disabled status, or genetic information.
To request disability accommodation in the application process, contact the Disability Services Office at 206-543-6450 or dso@uw.edu.
Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.
COVID-19 VACCINATION REQUIREMENT
Employees of the University of Washington are required to be fully vaccinated against COVID-19 unless a medical or religious exemption is approved. Being fully vaccinated means that an individual is at least two weeks past their final dose of an authorized COVID-19 vaccine regimen. As a condition of employment, newly hired employees will be required to provide proof of their COVID-19 vaccination. View the Final candidate guide to COVID-19 vaccination requirement webpage for information about the medical or religious exemption process for final candidates.
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